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In infants diagnosed with AD, thiols have been found to be significantly reduced compared to in comparison to healthy controls, while disulfide levels were markedly elevated, indicative of dysregulation in the thiol/disulfide balance favoring peroxidation (63)

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Studies have found that nearly half of patients with unexplained cholestatic liver disease after standard diagnostic workup had detectable gene variants for PFIC mutations in the ABCB4 and ABCB11 genes